Okay, So I don't usually link to stuff and do excerpts, but I just stumbled on an article about Depression, and the theory that it's not a seratonin-related thing at all, but an atrophy of braincells,Â and the "down" thing is simply a sideffect of the detoriation of the brain.
It is jarring to think of depression in terms of atrophied brain cells, rather than an altered emotional state. It is called "depression," after all. Yet these scientists argue that the name conceals the fundamental nature of the illness, in which the building blocks of the brain - neurons - start to crumble. This leads, over time, to the shrinking of certain brain structures, like the hippocampus, which the brain needs to function normally.